Discontinue use if acute or chronic disturbances of liver function occur. Increased risk of arterial & venous thrombotic & thromboembolic diseases (eg MI, DVT, pulmonary embolism) & CVA; VTE; cervical & breast cancer, benign & malignant liver tumours; pancreatitis in women w/ hypertriglyceridemia; HTN; jaundice &/or pruritus related to cholestasis; gallstone formation, porphyria, Sydenham's chorea, herpes gestationis, otosclerosis-related hearing loss. May induce or exacerbate symptoms of angioedema in women w/ hereditary angioedema. Irregular bleeding may occur. DM, SLE, hemolytic uremic syndrome, Crohn's disease or ulcerative colitis, sickle cell disease. May reduce efficacy w/ missed doses, GI disturbances or concomitant medication. Avoid sun or UV exposure in women w/ a tendency to chloasma. May influence the results of certain laboratory tests. Renal impairment. Not recommended during lactation.
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